Girvan Dempsey, Denis Hickie and Emmet Byrne will all take the field at Donnybrook on Friday evening.
Front row man Byrne has removed from a stomach bug and will start. Irish international full-back Dempsey was rated doubtful due to a reoccurrence of a groin injury, and Hickie, has recovered from an ankle strain. Hicke will start at wing alongside Gordon D' Arcy.
D' Arcy is the only change from the team which defeated Montferrand in Round 4 December.
Matt Williams' side, the Pool 4 leaders, need just one point to advance to the final eight of the competition, and they know a win will go along way in ensuring they are one of the best four qualifiers, therefore securing home advantage in the quarter-final.
The last time these sides met Leinster overpowered Swansea 51-10 in Round 2 - with Gordon D'Arcy bagging a hat trick.
Leinster: G Dempsey; D Hickie, B O'Driscoll, S Horgan, G D'Arcy; C Warner, B O'Meara; R Corrigan (capt), S Byrne, E Byrne, L Cullen, M O'Kelly, E Miller, K Gleeson, V Costello.
Reps: P Coyle, G Hickie, A McCullen, D Dillon, B O'Riordan, N Spooner, D Quinlan