It's a must win game for Munster and one that coach Alan Gaffney sees as: "As tough as anything Munster have ever played in Europe. This is tight group and we really need to win this one to give ourselves a chance of going through to the next stage.
"Now we saw Perpignan in action in Kingsholm when I felt they were a little unlucky, so when they beat Gloucester in the return I wasn't the slighest surprised because they are that good.
"They are a quality side, so we're under no illusions about the task that lies ahead, but we're looking forward to it and I think we'll give it a real good go."
"Of course it's a blow to lose players of the calibre of Paul and Anthony but then we're lucky to have quality players like Micko and Mossie to call on - Mossie's our leading try scorer with six tries and both he and Micko have come on in leaps and bounds this season. I've no worries whatsoever on that score."
Munster J Staunton; J Kelly, M Mullins, J Holland, M Lawlor; R O'Gara, P Stringer; M Horan, F Sheahan, J Hayes; D O'Callaghan, M O'Driscoll; J Williams (cap), A Quinlan, A Foley.
Replacements - J Blaney, M Cahill, M Galwey, D Leamy/E Halvey, M. Prendergast, K Keane, C McMahon.