Vaughan Going will take over from the British and Irish Lion at full back and Nick Walshe will play at scrum-half in place of Bryan Redpath.
"We made similar changes when we played pool leaders Llanelli at Stradey Park recently and got within a few minutes of a memorable victory," he said. "It has been a difficult period with some very demanding games and fresh legs could give us an edge.
"This will be a difficult game, especially as Bourgoin can still qualify for the knock-out stages. But we won't be under pressure and, if we play as we did last week, we are in with a chance," said Mallinder.
Sale, PARKER PEN SHIELD champions of last year, have found the step up to Heineken Cup rugby difficult, losing their first four games in the competition.
Sale: Vaughan Going; Mark Cueto, Jos Baxendell, Mel Deane, Steve Hanley; Charlie Hodgson, Nick Walshe; Kevin Yates, Andy Titterrell, Stuart Turner, Iain Fullarton, Dean Schofield, Apollo Perelini, Alex Sanderson, Stuart Pinkerton.
Replacements: Johnny Roddam, Barry Stewart, Chris Jones, Richard Wilks, Graeme Bond, Dan Harris, Richard Wigglesworth.