The Montferrand and Newcastle Falcons clash is one of them - and Montferrand coach Alain Hyardet is content his side don't have a bigger deficit to try to wipe out at Parc des Sports Marcel-Michelin on Sunday afternoon.
"I am pleased with the result we got at Newcastle," said Hyardet. "It's always difficult playing at English clubs considering the sheer number of quality players they are able to select.
"In order to continue our European adventure, we will have to apply ourselves on Sunday. We have worked hard on our defence but now we have to work on our execution in order to score tries. Our emphasis has to slide from defence to attack this weekend.
"However, though seven points seems little, we have to be vigilant because Newcastle play the ball a lot and it is difficult to score points against them - in that respect it could be seen as a substantial margin to wipe out.
"And English teams don't worry about whether they are playing away from home - they will just be determined to play well and conserve their advantage.
"We have to be on our guard and not count our chickens before they hatch. We will have to pull out some of our best rugby to qualify for the quarter-finals.
"Our matches against Leonessa helped restore some of the confidence that comes from winning and I hope that will continue after this Round.
"One of the reasons playing in this competition is important for us is that we have to learn to be disciplined because the referees are very vigilant. That is a good thing for us because we had a discipline problem earlier this season."