Gatland has opted to leave out Lawrence Dallaglio, Josh Lewsey, Rob Howley, Craig Dowd, Simon Shaw, Phil Greening and Fraser Waters.
These players will be rested but the England World Cup winners will be parading the Webb Ellis Cup before the game.
The pack sees Tim Payne, Trevor Leota and Will Green in the front row with youngsters, George Skivington and Martin Purdy in the second row. Joe Worsley slots in at No.8 with Paul Volley and Jonny O'Connor at six and seven respectively.
Volley has also been named captain. He becomes the third player to captain Wasps during this season's Heineken Cup campaign after Dallaglio (Perpignan / Celtic Warriors) and Alex King (Calvisano away).
Volley said, "Captaining London Wasps is an honour, especially in the Heineken Cup. Calvisano might not have won a game in this pool but they are very tricky customers. Not many sides score five tries against us but they did.
"We go into the game as favourites but we know it's not going to be easy. We slipped up in our last home game, something we can't afford to do on Sunday. If we want to progress in this competition, we must win".
The backline will see Peter Richards at scrumhalf with Mark Denney and Stuart Abbott in the centres. Tom Voyce has recovered from his ankle injury and will start at wing.
London Wasps: M Van Gisbergen; T Voyce, S Abbott, M Denney, J Rudd; A King, P Richards; T Payne, T Leota, W Green, M Purdy, G Skivington, P Volley (capt), J O'Connor, J Worsley
Replacements: B Gotting, A Mckenzie, I Clarke, M Lock, H Biljon, S Roiser, A Erinle