The fixture may have been reversed just over a decade ago, but the 33-6 home win by Munster to somehow claw their way into the quarter-finals remains part of the folklore of the Heineken Cup.
See match report from 'Miracle Match'
What is too often overlooked is the fact that Gloucester won the first leg of that Pool campaign 35-16 - and backed that up with a 22-11 triumph the next season when the two teams were drawn against each other once more.
There is no other option for Nigel Davies' side than to go for the jugular in the latest meeting between the two teams because a third Pool defeat will put an end to their chances of reaching the last eight of either the Heineken Cup or Amlin Challenge Cup.
"First and foremost we have to front up at the set-piece, then as a back-line we have to stay in the kicking battle and keep the ball in front of the pack," said England wing Charlie Sharples.
"It will be a massive challenge for us and the one thing we have learned from the Saracens defeat is we have to step up our game. Munster are similar to Saracens in the respect that they're a very clinical team.
"They have a good set of forwards, a solid set-piece, good defence and are generally a very difficult team to play. It's not a massively flash game, but they're good at what they do and when it goes behind to the backs in a broken field they throw the ball around.
"It will be a massive occasion, a full house and, hopefully, we will be able to raise our game and show some of the good stuff. We owe our supporters - they deserve better and it's about time we started producing the goods.
"Munster are one of the top teams in Europe for a reason, but we fronted up well at Thomond Park and if we do that at Kingsholm there's no reason why we can't get a result. It's all to play for, which makes it even more of a big game.
"Nothing is guaranteed for them and they have to come here and get a win while a victory for us will put us in a position where we can kick on."