Nigel Davies insists Gloucester Rugby just have to crack on with things after he learned they will be without both James Simpson-Daniel and Ryan Mills for the remainder of the Heineken Cup pool stages.
The backline duo underwent surgery this week and will miss the December double header with Edinburgh and the January battles at home to Munster and away in Perpignan.
Simpson-Daniel faces up to six months on the sidelines following an operation on his left ankle, while Mills will be absent for 10 weeks as he recovers from a broken foot.
Davies admits it is a big blow for the West Country outfit but he insists they have no option but to put it behind them as they search for improvement in the Aviva Premiership and a first Heineken Cup quarter-final appearance since 2008.
"It's disappointing for the pair of them as individuals, and for us as a group. But that's where we are and we have to get on with things," said Davies, who saw both players leave the field on a stretcher during the second quarter of the 20-3 LV= Cup win over Newcastle Falcons last weekend.
"Ryan Mills has fractured his fifth metatarsal in his left foot. He's had surgery, it's been pinned back and he will be out for between six and ten weeks.
"Sinbad's (Simpson-Daniel) injury is obviously a little bit more serious. He's dislocated and fractured his left ankle, and that will be anything between four to six months. It's early stages, but obviously it was a severe injury with quite a lot of damage there.
"But the surgeon is pleased with the results of the operation and it's now all about the rehabilitation over the forthcoming months and we'll see how quickly we can get him back."
The news is particularly badly-timed for both men, with Simpson-Daniel just one game short of Gloucester's all-time appearance record currently held by Peter Buxton and Mills having not long recovered from a serious knee injury that wrecked his first few months of last season.
"They've both performed very well. Ryan, in particular, in terms of coming back from a long-term injury himself, it's been great to see him get a run of games," added Davies.
"He's been going exceptionally well, he's a lovely ball playing No12 and has been able to bring other players into the game. He's made a significant impact upon our performances. And we all know what James can do. He's a fantastic player."
The atmospheric Stade Vélodome in Marseille looks set for a 40,000 plus attendance for the Heineken Cup semi-final clash on Sunday, 27 April between reigning champions, Toulon - gunning for a fourth European final in five years - and Munster Rugby, who have reached a record 11th tournament semi-final.