Only three of those who started against Leinster last weekend remain in the Munster starting XV - Denis Hurley, Ian Keatley and Damien Varley - while the rest of the team is made up of those players who played in the British & Irish Cup win over Cornish Pirates a fortnight ago.
Munster may not be able to qualify for the Play-Offs in their domestic league, but the game in Wales will still be important for the players involved, as outside half Ian Keatley was quick to point out.
"Obviously the main focus for the season now is the semi-final, but there is still a lot of guys here with a lot to prove," said Keatley.
"There are still contracts up for grabs and still lads who haven't got many opportunities so far this year. I think they have got the job this weekend to go out and prove that they are up to the standard. They have to grab their own careers by the hand."
Penney is still hoping that three of his top flight players, club captain Doug Howlett, Irish centre Keith Earls and experienced lock Donncha O'Callaghan, will return to full fitness next week in time to compete for places in the team to take on Clermont.
"Keith is making progress. We were hopeful he would have been available this weekend, but he just didn't come through training. He's close but we'll know more at the end of the week," said Penney..
"Doug's trying hard, making slow progress but, I'd have to say, that's still right up there. Donncha never gets injured and for him to sustain the injury he's got is very frustrating.
"Donncha has no structural damage, but it's one of those ones that could be two weeks or it could be one. He just has to see the specialist at this stage."
Munster (v Dragons): D Hurley; R O'Mahony, I Dineen, JJ Hanrahan, J Murphy; I Keatley, C Sheridan; W du Preez, D Varley, S Archer; D Foley, B Holland; Dave O'Callaghan, N Ronan, P Butler. Replacements: S Henry, M Horan, J Ryan, I Nagle, CJ Stander, D Williams, C Bohane, D Barnes.