It will, in fact, be O'Driscoll's first appearance for Leinster since the Round 6 Heineken Cup Pool win at Exeter Chiefs but there is still no sign of Irish outside half Jonathan Sexton returning after his foot injury in Rome. The No 10 jersey stays in the safe hands of Ian Madigan, who took his season's tally to 202 in 29 games with 28 points in the win over Wasps.
Shane Jennings, who missed the Amlin Challenge Cup quarter-final through illness, returns to a back row that will see Sean O'Brien make his 80th appearance in the Leinster colours.
Leinster will be on the road again next weekend when they travel to Italy to meet basement boys Zebre in their penultimate PRO12 fixture. They return to the RDS on Saturday, 27 April to face the Amlin CC holders Biarritz Olympique in rthe 'Champions Challenge' between the two European winners from 2012.
At stake is a possible dream home final at the RDS on Friday, 17 May against the winners of the first Amlin CC sem-final between Perpignan and Stade Francais Paris.