Leinster take on London Wasps at Adams Park on Friday night with the ultimate target of lifting a fourth European title in just five seasons - and becoming the first non-English club to do the double.
The three times Heineken Cup winners will be making their Amlin Challenge Cup debut in the high profile quarter-final and bidding to match their last eight opponents, Bath and Northampton Saints in getting their hands on both the Heineken Cup and Amlin Challenge Cup silverware.
The Adams Park victor will have the prize of home advantage against either Gloucester or Biarritz Olympique in the semi-finals three weeks later with the final on 17 May at Leinster's base at the RDS.
"In this competition it's about trying to get back to a home semi-final," said Leinster head coach Joe Schmidt.
"We think we have probably let that slip in the PRO12 so it would be nice for our supporters to have one at home. A European trophy is a European trophy. It's maybe not the one we initially would have liked but it's still one we would like to win."
The 2009, 2011 and 2012 champions of Europe have qualified for the last eight of the Amlin Challenge Cup as one of the Heineken Cup Pool runners-up and will be meeting Wasps for the fourth time in a European contest.
The Premiership club is 2-1 ahead on those Heineken meetings - including a 35-13 home victory in the 2007 quarter-finals - while Schmidt is also no stranger to the challenges of an Adams Park contest.
It is just over five years since Schmidt tasted defeat at the ground as assistant coach with ASM Clermont Auvergne, losing out 25-24.
"We played a thriller there," recalled Schmidt. "It was three tries apiece, so it might be a tight pitch but if you can get a bit of continuity and get the ball out wide and a bit of speed in your play you can score."
As part of the build-up to next month's Cardiff 2014 Heineken Cup and Amlin Challenge Cup finals weekend, ERC has joined forces with the WRU, Cardiff Blues and adidas to develop an annual grassroots community rugby programme targeting young players.
The Ulster Rugby full back, Jared Payne (No 15), has been suspended for two (2) weeks following an independent Disciplinary Hearing in Dublin arising from the Heineken Cup quarter-final match against Saracens at Ravenhill Stadium on Saturday, 5 April.