The high-profile tie between the innovative English club and last season's defeated Heineken Cup finalists goes ahead on Saturday, 6 April (kick-off 6.30pm) and is set to feature a host of star players such as Saracens' Owen Farrell, Chris Ashton, Brad Barritt and Alex Goode along with Stephen Ferris, Tommy Bowe, Rory Best and John Afoa for Ulster.
In addition, the game will have a strong South African flavour with the likes of Schalk Brits, 2007 World Cup-winning captain, John Smit, and Ernst Joubert coming up against compatriots Ruan Pienaar and Johann Muller.
The fixture's appeal is further strengthened by the connection between the rival Directors of Rugby, with Saracens' Mark McCall, who was Ulster's captain when they were crowned European champions in 1999, looking to outwit his former teammate David Humphreys.
With an expected big attendance at Twickenham in April, the UK record of 37,881 for a Heineken Cup quarter-final set at Murrayfield in 2012 (Edinburgh Rugby v Toulouse) could well be broken, while the tournament record of 55,000 for a last-eight match set in 2011 at the Olympic Stadium in Barcelona (Perpignan v Toulon) could also be under threat.
Buy tickets now from Ticketmaster
Tickets are also available at saracens.com or fans can phone Saracens' Supporter Services on 01727 792 800.
Tickets can also be purchased from Ulster Rugby by logging on to ulsterrugby.com
Category 1: £50, *£25
Category 2: £40, *£20
Category 3: £30, *£15
Category 4: £20, *10
*Over 65s, under 16s and full-time students