Now the Pro12 match against Benetton Treviso at Murrayfield will double as a send-off party for the departing players.
Six months after retiring from the international scene, 109-times capped Paterson will bring an end to one of the most famous playing careers in Scottish rugby history.
The nation's top points scorer and record male cap holder will take up a new non-playing role with Edinburgh Rugby and Scottish Rugby with further details announced next week.
"We've enjoyed an historic season in the Heineken Cup this year with a number of memorable matches here at Murrayfield," said Edinburgh head coach Michael Bradley.
"Saturday will be a memorable match for a number of reasons; we'll bring the curtain down on an incredible season, say farewell to these fine players and, at the final whistle, look to the future and begin preparations to capitalise on this landmark year."
Mike Blair, who confirmed his departure a fortnight ago, will be joined by long-standing servants Phil Godman and hooker Andrew Kelly, with the 23-times Scotland capped stand-off set to join Edinburgh Rugby's 150 club with an appearance this Saturday.
The club will also bid farewell to popular flanker Alan MacDonald, who first joined the club as an apprentice in 2004 and went on to make 98 appearances for the club. He has been capped four times for Scotland, in the 2009 Autumn Tests and in the 2010 RBS 6 Nations.
Kelly's front-row colleagues, Scotland-capped Kyle Traynor and Jack Gilding, ever-presents in this season's landmark campaign, are also leaving the club, as are Argentine lock Esteban Lozada and full-back Jim Thompson.