Paddy Wallace, Rory Best, Darren Cave, Tom Court and Pedrie Wannenburg all crossed the opposition line to hand Ulster a sixth win in seven league games since late December, with the hosts also being awarded a penalty try.
A narrow defeat to the Blues in mid-February is the only blight on Ulster' RaboDirect PRO12 copybook in 2012, while their two latest Heineken Cup appearances have featured hugely promising performances.
Ulster thrashed former tournament winners Leicester 41-7 in Belfast in Round 5 of Europe's premier club competition, before coming agonisingly close to ending ASM Clermont Auvergne's incredible home record at the Stade Marcel Michelin a week later.
Meanwhile, Cardiff Blues will have to bounce back from another league defeat if they are to topple Heineken Cup kings Leinster in Dublin this Saturday.
Having been beaten at home by the Scarlets last weekend, the Blues slipped to a 31-3 reverse against Glasgow Warriors on Friday night.
Defeat leaves their chances of reaching the RaboDirect PRO12 hanging by a thread but, more worryingly, the nature of their showing at Firhill means they will need to improve significantly to make the Heineken Cup semi-finals for the first time since 2009.
The Blues conceded four tries and could only muster a single Leigh Halfpenny penalty in Scotland as they failed to transfer their European form on to the domestic stage.
There could be more bad news for the Blues as well after star centre Jamie Roberts hobbled off on 53 minutes.
The Wales and Lions international twisted his left knee when attempting to tackle Stuart Hogg just inside his own half.
Roberts damaged the same knee in Wales' Triple Crown clinching win over England in February but the Blues medical staff have suggested that his substitution was a precautionary measure ahead of the trip to the Aviva Stadium.