The English champions, who face ASM Clermont Auvergne in the last eight of the Heineken Cup at Vicarage Road on Sunday, 8 April, also have Mouritz Botha in the second row and prop Matt Stevens on the bench.
The match 22 sees five more uncapped players among the replacements - Rob Webber (London Wasps), Geoff Parling (Leicester Tigers), Ben Morgan (Scarlets), Lee Dickson (Northampton Saints) and Jordan Turner-Hall (Harlequins).
Head Coach Stuart Lancaster said: "We have been impressed with how the whole group has come together in the last 10 days and we have done a lot of work on and off the field. Now is the time to turn all that into a performance against Scotland that we can all be proud of. It is a massive challenge - Murrayfield, the first game of the Six Nations - but one we are relishing."