But the Chiefs have recorded a precious losing bonus point which is the difference between the two sides and gives them a vital edge in the bid for a Amlin Challenge Cup quarter-final place.
Perpignan won the first meeting between the two sides 15-12 at the Stade Aime Giral before Christmas, against a Chiefs outfit in only their second season of European rugby.
Newport Gwent Dragons v I Cavalieri Prato
(Saturday January 21, KO 15:00)
Newport Gwent Dragons will be looking to finish off their Amlin Challenge Cup campaign on a high with a victory over I Cavalieri Prato at Rodney Parade.
The Men of Gwent ran out 33-3 victors when they beat the Italian minnows, who have yet to register a point or a win in the Pool, away from home at the start of this European campaign.
The Welsh region and the Italian Super 10 side only have European rankings to play for in the last game of their European season and cannot qualify for the Amlin Challenge Cup quarter-finals..