Bordeaux Begles, back in European competition for the first time in a decade, may be third in the Pool but they will be determined to keep their own slim hopes of qualification simmering with a home win.
Both teams know the English side are in the driving seat in the Pool but they will want to make sure they are still in the mix for a place in the last eight when they play their final games next weekend.
Femi-CZ VEA Rovigo v London Wasps
(Saturday January 14 KO 15:00)
Pool 3 leaders London Wasps travel to northern Italy looking to take a step closer to a sought after Amlin Challenge Cup quarter-final spot.
Victory over Bayonne at Adams Park in the last round put Dai Young's side in the driving seat and they will be looking for a repeat performance when they face Rovigo.
When the two sides last met in Round 2 Wasps collected a bonus point 38-7 victory but the task will be much more difficult at the Stadio Mario Battaglini.
Rovigo find themselves bottom of the Pool after four rounds and are still without a victory to their name.
In fact their last win in the tournament came back in 2008 against Dax.