The Italian side, who are in only their second season of European competition, are still looking for their first victory in this season's Pool but face a daunting task against the Top 14 side.
Newport Gwent Dragons v Exeter Chiefs
(Sunday December 18)
The Newport Gwent Dragons know they need a home victory over the Exeter Chiefs at Rodney Parade to keep them in race for a qualification spot for the knockout stages of the tournament.
The Chiefs, who are the Pool leaders after they recorded a 18-6 victory over the Welsh side last weekend, know an away win will put them in the driving seat with two rounds of games to come after Christmas.
The Men of Gwent, the Chiefs and Perpignan are all still in the hunt for a quarter-final place in the Amlin Challenge Cup and cannot afford a slip up with only one points separating the three sides on the Pool.