Leicester, the only team to successfully defend the Heineken Cup after winning it in 2001 and 2002, have started this season with two victories in Pool 4.
They now face back-to-back games against Clermont Auvergne and director of rugby Richard Cockerill is delighted to have the duo back in contention ahead of the trip to the Stade Marcel Michelin.
"Manu should be fit. He has had the all-clear from the specialist so that is good news and Tom Croft should be fit as well," he told the Leicester Mercury.
"Having Manu back gives us some good options in the centres with Billy Twelvetrees and Matt Smith in there.
"With regards to who should start and who should go on - well, it's a great headache to have. I have spent most of the year trying to find two centres. This weekend, I will have three.
"There are enough games left this season for everyone to play their part but, with Manu fit and available, the likelihood is that he is going to play because he is pretty good.
And Cockerill was full of praise for Saturday's opponents.
"They have lots of world-class players in the squad," he added.
"Other sides have 15 of them. They have 35.
"But we will go there to try to win. It's the only way to do it and, if we do, it puts us in pole position in the pool.
"There is no point in trying for a losing bonus point. We are going there for four points and we will give it our best shot.
"There will be lots of noise and you just have to embrace it.
"It's a huge challenge but I have no doubt that, if we get it right, we can go there and win.
"They are second in the French championship, they have the best attack and the second-best defence. But why not go there and enjoy the battle and give it a crack?"