Monye made his Harlequins debut in 2002 and has gone onto make 169 appearances, 29 of which have been in European competitions.
"I have so many wonderful memories here at Quins," he said.
"Reaching the semi finals of the Premiership in 2009 and, more recently, the win against Munster and Stade Francais in the Amlin Challenge Cup, are moments I will treasure, along with making my debut for England and the Lions.
"I am so proud to be a part of this club, and I am looking forward to extending my time here by at least another 3 years.
"I would like to say a massive thank you to all the supporters, players and coaching staff who have supported me and believed in me over the last 10 years. I am proud to be part of the history of this amazing club".
Harlequins are unbeaten in all competitions this season and face crucial back-to-back matches against Toulouse in Pool 6 of the Heineken Cup, the first coming on Friday at the Stoop.