Bucharest Wolves got their 2011/12 campaign off to a flying start by beating Italian side Crociati 34 v 7 at home last weekend.
They will look to carry that form on this weekend but found it hard going against Stade Francais when the two sides met at the same of the tournament last year losing 29 v 20 at home and 35 v 7 away to the French side.
Banca Monte Crociati v Worcester Warriors
(Saturday November 19, KO 7:30)
Worcester slipped to an opening defeat in the Amlin Challenge Cup last week on their return to the competition and they will look to right those wrongs when they travel to Italy on Saturday.
Richard Hill's side have never lost to an Italian outfit in the competition but haven't won a game in their last four outings so will have to improve in Parma.
Crociati's European campaign got off to a disappointing start as they were beaten comprehensively by Bucharest Wolves.
Their record in Europe shows just one win to their name and they will need to improve for the visit of the English Premiership side.