Bayonne haven't reached the knock-out stage of a European competition since 2006 so will be looking to record a home win to keep up their unbeaten start.
Bordeaux had a tough return to the Amlin Challenge Cup falling to a 47 v 14 defeat to Wasps but will take confidence from a meeting earlier in the season between the sides in the French TOP14 which Bordeaux won 18 v 6.
London Wasps v Femi-CZ VEA Rovigo
(Sunday November 20, KO 15:00)
Dai Young's side will go into the game against the Italian side in confident mood following their impressive 47 v 14 opening victory away to Bordeaux-Begles at the weekend.
Wasps scored six tries on their way to beating the French side and laid down their marker in this year's competition
The former Heineken Cup and Amlin Challenge Cup Champions have never lost to an Italian side in the competition and will be looking to make it two from two on Sunday.
Rovigo kicked off their 2011/12 campaign with a 43 v 10 home defeat to Bayonne.
They head to London in search of their first win in the competition in three years, whilst you have to go back to 2000 for their last win away from home and that came on English soil when they beat Bedford 20 v 10.