In the pack Joe Gray and Maurie Fa'asavalu come into the side for the clash at the Rec, the latter making his first league start of the season. Conor O'Shea also sees the return of England scrum-half Danny Care to his match-day squad and he will take his place on the bench.
Harlequins host Heineken Cup debutants Connacht in the opening game this season and the pair will renew old rivialaries having met each other in the Pool stage of the Amlin Challenge Cup last season.
Gloucester travel to Exeter looking for their first victory on the road in any competition since March.
England centre Mike Tindall makes his first start for the Cherry and Whites following his World Cup duty and will look to help his side bounce back from suffering their first home defeat since December 2010 at the hands of Saracens last weekend.
The West Country side find themselves in 8th place in the Premiership with three wins from their opening seven ties.
English Champions Saracens return to Vicarage Road to face Sale Sharks this weekend and will be buoyed after a hard-fought victory at Kingsholm over Gloucester last weekend.
Benetton Treviso are the visitors to North London in a week's time and for the final game before the Heineken Cup begins, Mark McCall welcomes back Chris Wyles from World Cup duty and Deon Carstens starts at loose-head prop.
Recent form has seen Saracens rise to second in the table with six wins from their last seven matches.
Martin Castrogiovanni and Louis Deacon make their first starting appearances for former Heineken Cup Champions Leicester Tigers on Saturday when they host London Irish.
They are still missing a host of players through injury ahead of their first European tie away to Aironi on Saturday November 12, including, Ben Youngs, Manu Tuilagi, Mathew Tait, Anthony Allen and Billy Twelvetrees.
The Tigers claimed only their second Premiership win of the season last weekend against Sale and will look to add to that tally this weekend against the Exiles before the Heineken Cup gets underway.
Bath make three changes for their tie against league leaders Harlequins this weekend. On the back of an away victory at London Irish, Bath welcome David Wilson into the front-row for the first time this season. Francois Louw and Dan Hipkiss also return to the starting line-up.
They then travel to Glasgow in their opening European tie and will look to take some of the form from the Premiership, which has seen them rise to fourth, into the game.
London Irish's World Cup trio of Alex Corbisiero, Sailosi Tagicakibau and Jebb Sinclair will start for the Exiles Saturday afternoon when they take on Leicester Tigers at Welford Road.
Jebb Sinclair will start his first game for London Irish at number 8 and Alex Corbisiero and Sailosi Tagicakibau will start their first games of the season at prop and on the wing respectively.
London Irish host Edinburgh on the opening weekend and their recent form has seen them loose two our of their last three Premiership games.