Flanker Paul Derbyshire earns his first start of the tournament while hooker Leonardo Ghiraldini and prop Salvatore Perugini return to the team and second-row Quintin Geldenhuys is promoted from the bench.
will also start after being relegated to the replacements bench against France.
Italy are currently fifth in the standings, two points clear of bottom side Scotland.
Italy will go into the game with further confidence having beaten their opponents in three of the last four encounters between them, including a victory at Murrayfield in 2007.
Italy: Masi (Racing Metro); Benvenuti (Treviso), Canale (Clermont Auvergne), Sgarbi (Treviso), Mirco Bergamasco (Stade Francais); Burton (Treviso), Semenzato (Treviso); Perugini (Aironi), Ghiraldini (Treviso), Castrogiovanni (Leicester), Del Fava (Aironi), Geldenhuys (Aironi), Zanni (Treviso), Derbyshire (Treviso), Parisse (Stade Francais).
Replacements: Festuccia (Racing Metro), Lo Cicero (Racing Metro), Bernabo (Treviso), Barbieri (Treviso), Canavosio (Aironi), Orquera (Brive), McLean (Treviso).