Leicester flanker Tom Croft makes his return to the match day 22 after recovering from a broken shoulder and is joined on the bench by Gloucester prop Paul Doran-Jones.
Simon Shaw retains his place in the 22 despite lock Courtney Lawes returning to the squad for training this week.
As expected, Toby Flood starts at fly-half after recovering from an Achilles injury sustained in the win over France.
Croft returns to an England squad for the first time since fracturing his shoulder against South Africa in the final Test of the autumn campaign.
Ben Foden (Northampton); Chris Ashton (Northampton), Mike Tindall (Gloucester, captain), Shontanye Hape (Bath), Mark Cueto (Sale); Toby Flood (Leicester), Ben Youngs (Leicester); Alex Corbisiero (London Irish), Dylan Hartley (Northampton), Dan Cole (Leicester), Louis Deacon (Leicester), Tom Palmer (Stade Francais), Tom Wood (Northampton), James Haskell (Stade Francais), Nick Easter (Harlequins).
Replacements: Steve Thompson (Leeds), Paul Doran-Jones (Gloucester), Simon Shaw (Wasps), Danny Care (Harlequins), Jonny Wilkinson (Toulon), Matt Banahan (Bath).