The fixture at Stade Pierre Rajon creates a milestone for the Chiefs but they face a stern test against experienced former champions Bourgoin.
Both teams will be eager to kick-start their European campaign with a win after losing their opening games,
Exeter No.8 Richard Baxter returns to action after four months out with a shoulder injury.
He said "I'm just really pleased to be back playing and being involved. We expect them to come out hard in the first 10-15 mins."
Bourgoin have won five of their last eight games in the competition and will look to stay in touch with early-pace setters Montpellier. The French club currently sit at the top of their pool following their 32-8 victory over Newcastle in the round two opener on Thursday night.