Sale will be hoping Tom Brady and Nick MacLeod's can repeat their heroics of last week and that form will be as incisive as it was against the Spanish side.
England international Matthew Tait returns at full back to give the team added quality and extra cutting-edge.
Speaking ahead of the game Tait said: "I am very keen to make up for lost time. The knee operation was to clean out some debris and I feel great now and can't wait to get a good run of games playing for Sale Sharks under my belt."
Petrarca Rugby will be hoping to salvage something against the English giants, who have won the competition twice, after their defeat by Brive.
Brive travel to Campo de Pepe Rojo to face El Salvador.
The 1997 Challenge Cup champions will look to continue their good form after beating Petrarca 32-6 before returning to European action against the Sale Sharks on the December 11.