Edinburgh are still able to qualify for the knock-out stages, although an Amlin Challenge Cup spot is more likely than a Heineken Cup one, as Pool 6 hots up this weekend.
They have had some excellent results at home recently while Perpignan, endured a miserable 2013 away from France, and scrum-half Greig Laidlaw believes Edinburgh's home form could help them spring a surprise and qualify.
"Traditionally, in the Heineken Cup, we have done pretty well against French sides," said Laidlaw.
"If you look at Edinburgh's history, we have put away Racing Metro, Toulouse, Stade Francais, and Perpignan - before my time - as well. French teams don't like coming here and we need to make sure they have that feeling this weekend.
"These are the tournaments we want to play in and everyone in the club wants to be associated with. So this is a massive game for us this weekend and we hope we get a big crowd out to support us.
"If we win this game, if we get to put ourselves in a good position and push on later in the game, that would set us up to go over and play Munster and we could still be in the mix to go through."
Perpignan have won two of their three meetings with Edinburgh, including a 31-14 success in the Scottish capital earlier this season. The French side eased their Top 14 relegation fears last weekend with a 20-8 win over Bayonne.
- Perpignan have won two of their three meetings with Edinburgh (L1), including a 31-14 success in the Scottish capital earlier this season.
- Edinburgh's Cornell Du Preez is the top tackler in the tournament heading into Round 5, having completed 58 of his 62 attempted tackles. Teammate Grant Gilchrist has made the most tackles without a miss so far (43).