The Aviva Premiership side must win if they want to have any hope of qualification from Pool 1 but the stats don't make for good reading for the Saints.
Leinster have won 15 of their last 16 home games in the competition, their only defeat coming to French powerhouse Clermont Auvergne last season.
The Irishmen have also conceded the least amount of points so far in this year's competition (23 points) and have the best tackle success rate (92%) of any side in the Heineken Cup.
"We cannot hide from last Saturday, but we can't let it define us either," said Northampton Director of Rugby Jim Mallinder.
"This week we have an immediate chance to show how quickly we can learn and how much we want to compete with a side who have been one of the best in Europe for a number of years.
"Leinster have shown us the level we need to be at to succeed at the top of the game, and it was a significant step up from any other match we've played so far this season.
"It's going to take a lot of hard work and commitment, but we believe we're better than we showed on Saturday, and we will be putting everything into getting things right for the next few weeks and beyond."