Their latest heartbreak came at the hands of European heavyweights Leinster last season. The Dublin-based outfit ran riot at the RDS and claimed an emphatic 34-13 victory.
But Stade will return to European action against a far less experienced team in Portuguese newcomers Lusitanos XV on Thursday night.
Drawn in Pool Five, alongside I Cavalieri Prato and London Irish, the Stade Jean Bouin clash will be one in which Stade will be targeting a maximum points haul, even though head coach Gonzalo Quesada has rested several key players including Jules Plisson, Julien Dupuy, Hugo Bonneval and Pascal Pape.
Despite the absentees the French club will still present Lusitanos with a colossal challenge. The combination team boast 14 Portuguese internationals in their side and both Vasco Uva and Joao Correia have experienced European action with Lisboa.
Head coach Frederico Sousa, also the top man of the national side, is under no illusions of the magnitude of the task facing Lusitanos, but he reckons it will be of huge benefit to the development of rugby in Portugal.
"We have to be realistic and have a good idea of the difficulties that lie ahead of us," said Sousa.
"We will have to be objective in terms of performance and not in terms of results.
"Playing in the Amlin Challenge Cup will bring benefits to the game in Portugal in the medium and long term."