By contrast ASM Clermont Auvergne have never managed to qualify for the prestigious tournament final and are through to the last four for only the second time.
But while Munster may have the monopoly on experience Clermont are the only team through to the semi-finals to have won all seven of their tournament contests and will enjoy "home country" advantage at Stade de la Mosson in Montpellier on Saturday evening.
They failed to make that advantage count a year ago when they went down 19-15 to eventual winners Leinster in Bordeaux but they will be all the better for that painful experience.
However, Paul O'Connell and his Munster team-mates have a special affinity with the Heineken Cup and nothing brings out the best in them than a European challenge.
They insist they are out-and-out underdogs - "there is no doubt that Clermont are roaring hot favourites and we're underdogs," said Munster coach Rob Penney - but it was much the same when they travelled to Harlequins in the quarter-finals.
Quins had sailed through the group stages with six from six but Munster stunned the Stoop faithful with an 18-12 triumph, a victory built around a colossal all-round performance from the returning O'Connell.
Munster qualified for the knock-out stages as one of the best runners-up behind Pool 1 winners Saracens - losing on the road at Racing Metro 92 and Saracens - while Clermont scored 23 tries in doing the Pool 5 doubles over defending champions Leinster, Exeter Chiefs and the Scarlets.
It all adds up to them boasting both the leading points and try scorers in Morgan Parra (97 points) and Napolioni Nalaga (six tries) - not to mention Wesley Fofana joint second top try scorer on five.
Clermont coach Vern Cotter has a galaxy of world class stars in his squad but will be wary of how Munster's love affair with the tournament brings out the best in the Irish side when the chips appear to be well and truly down.
- Clermont are the only semi-finalists to maintain a 100% record this season, they have won seven from seven, a club record run in this tournament.
- Munster have faced French opposition on 50 occasions in this tournament, more often than any other nation. They have won 34 of those matches.
- Napolioni Nalaga is the leading try scorer in the Heineken Cup this season (6) with Wesley Fofana (5) joint second on the list alongside Alex Cuthbert.
- Munster have missed fewer tackles per match (7.3) than any other side in this year's competition.
- These sides have met on four previous occasions in this competition, with each side securing two wins and all four of these wins coming as home victories.