More than 14,000 fans will create a superb vibrant atmosphere and Perpignan outside half James Hook, who has also visited the ground as an opposing player, admits it gives the Catalans an edge.
"The crowd here are incredible and playing at home will be a big factor," said the Wales star. "I came here with the Ospreys in 2009. It was a pretty special experience and one of the reasons I signed with Perpignan.
"It will be pretty daunting but it's also something you look forward to as a visiting player."
They have already inflicted defeat on the Parisians at Stade Aime Giral this season with a 32-16 Top14 victory in February but honours are even between the rivals with Stade winning their home tie.
The match also provides the last chance for Hook to convince Warren Gatland that he is worthy of a place on the British & Irish Lions tour of Australia.
While both sides are regular contenders at the knock-out stages of European competition, neither have clinched silverware.
Perpignan have reached four European semi-finals and were Heineken Cup finalists in 2003, while Stade Francais have reached seven and twice been runners up in the top tier competition.
Both sides will be desperate to go a step further this season and there will be the added incentive of automatic qualification for the 2013/14 Heineken Cup.
Stade have not competed in Europe's premier club competition since 2009 and go into this Amlin Challenge Cup clash on the back of mixed form, in which they have won just three of their six matches since losing to Perpignan.
But they possess plenty within their armoury with 2009 Heineken Cup winner Paul Wawrick, France captain Pascal Pape and Italy skipper Sergio Parisse in their ranks.
• Stade Francais have averaged 35 points per match in the tournament this season and 30 more would take them to the 1,500 barrier in this tournament overall.
• Perpignan have averaged a gain of 606 metres per match in the tournament this season, higher than any other club left in either ERC competition.
• Stade have lost two of their last three games against French opponents (Grenoble and Toulon) in this competition.
• Stade are making their third successive appearance in the Amlin Challenge Cup semi-finals, they reached the final in 2011 but lost at this stage last year.
• Adrien Planté and Francis Fainifo are joint-top try scorers in the Amlin Challenge Cup this season with six apiece (along with two others).