Four-time champions Toulouse lead the Pool from the Tigers by two points after their 35-14 bonus point victory over Italian outfit Benetton Treviso at home in the last round.
Leicester, who won the Heineken Cup back in 2001 and 2002, scrapped a 15-15 draw with the Ospreys in the Liberty Stadium in Swansea to keep their hopes of a place in the knock-out stages alive.
Toulouse recorded a comfortable 23-9 victory over Richard Cockerill's side in the first game between the sides back in October but will be aware the Tigers will be a different proposition at home in front of a sell-out crowd of 24,000.
The French giants, who won this tournament in 1996, 2003, 2005, 2010, have an impressive pedigree in Europe and last failed to reach the knockout stages of the Heineken Cup back in 2007.
The Tigers will be desperate to secure a place in the last eight, having failed to make the quarter-finals of European rugby's premier tournament for two of the last three seasons.
- Leicester are unbeaten in their last 21 home games in the Heineken Cup since Munster Rugby won 21-19 at Welford Road on 22 October 2006.
- Leicester's only win in their last five encounters with French opponents was 23-19 over ASM Clermont Auvergne at Welford Road on 17 December 2011.
- Toulouse's only Round 6 victory since 2008 came at Sale Sharks (19-13) in January 2010.
- Leicester have won three of the clashes between these sides, while Toulouse's victory over the Tigers earlier in the campaign was their fourth win against their long-standing English rivals.
- The only time that Toulouse have missed out on a quarter-final spot since 2001/02 was in 2006/07.