The Dubliners, who have won three of the last four Heineken Cup finals, managed to come away with a 33-14 bonus point victory over the Scarlets in Dublin in the last round.
Ireland captain Brian O'Driscoll was a late replacement against the Scarlets as he continues his comeback from an ankle injury and Leinster will need all of his experience at this stage of the tournament.
The Irish province, who lifted the trophy in 2009, 2011 and 2012, will be wary of their away trip to face the Chiefs who have an impressive reputation on their home ground.
The English Premiership side only lost 9-6 when they two sides met in Dublin in the opening game of this Pool and they would relish the chance to become the side that knocked the champions out of the competition.
Leinster are facing the prospect of missing out on a place in the last eight of the Heineken Cup for the first time in five years - they last failed to reach the quarter-finals back in 2008.
- Exeter Chiefs have won six ERC matches and lost only two at Sandy Park.
- Leinster have not been defeated in a Round 6 encounter since they visited Leicester Tigers in 2007/08.
- The only Heineken Cup holders to have failed to make it out of the pools since 2000 are London Wasps, who faltered twice in 2004/05 and 2007/08.
- The only time that Leinster have not made it to the last eight since 2003/04 was in 2007/08.
- Leinster have won their last seven contests against English opponents since drawing 11-11 with London Irish at Twickenham in Round 6 in 2009/10.