They won the Round 1 encounter on French soil 59-3 thanks to five of their nine tries coming from replacements as they used their bench early on.
Wing Nicholas Laharrague added four conversions and the French club will be looking for something of a repeat in the return tie.
- Grenoble have only ever won back-to-back away games once before in this competition, beating Leeds Tykes and Beziers in 2004.
- The French side have a 100% record against Italian sides in this competition, accruing an aggregate score of 135-19 in the process.
- Since defeating Connacht Rugby on their European debut in October 2010, Cavalieri have lost 16 consecutive matches in this tournament, conceding an average of 49 points per game.
- The Italian club have notched up 54 points in their two home games so far this season, being edged out by London Welsh by one point while losing by 14 to Stade Francais Paris.