Toulon recorded a hard-fought 22-14 victory over the Cardiff Blues at the Arms Park back in October and will be favourites to get the win when the two sides meet on French soil.
But Toulon, who are the Top 14 leaders, suffered their first home defeat of the season when they lost 19-15 to Racing Metro 92 last weekend and will want to get back to winning ways against the Blues.
The Welsh side, who have no chance of a Heineken Cup quarter-final place, will be hoping to build on their shock victory over Munster on Irish soil in the Pro12 last weekend.
The Blues will also be hoping to replicate the performance which saw them become the first Welsh side to lift a European trophy when they beat Toulon 28-21 in the Amlin Challenge Cup final in Marseille back in 2010.
A young and new-look Cardiff Blue side will be under no illusions of the task facing them and the likely backlash which Jonny Wilkinson and company could inflict on them.
- Cardiff's eight-point defeat to Toulon earlier this season was the closest any side in Pool Six has ran the French side.
- Toulon have gained an average of 579 metres per game so far this season, the highest figure in the Heineken Cup. They also average the most clean breaks (12).
- Cardiff Blues have the lowest tackle completion rate in the tournament (85%).
- Toulon are the only team in the Heineken Cup to average under 10 points conceded per game (36 conceded in four matches).
- Cardiff's Alex Cuthbert has scored four tries in the competition so far, the joint-most.
- David Smith, the Toulon winger, has made more metres, clean breaks and gone past more defenders than any other player in the tournament.