The Top 14 side are the Pool 5 leaders after a stunning 28-21 victory over the reigning champions, Leinster, in front of a 48,964 crowd at the Aviva Stadium in Dublin in the last Pool game.
Clermont's victory has put them firmly in the driving seat for a place in the last eight of the tournament and they could qualify, if they beat Exeter, with a Pool game still to play.
The French side, along with fellow French outfit and Top 14 leaders, Toulon, and English champions, Harlequins, are one of only three sides still unbeaten in the Pool stages of the Heineken Cup.
Exeter, who cannot qualify for the Heineken Cup quarter-finals, come into this game having recorded back-to-back victories over the Scarlets in their last two Pool 5 games.
The English side face a daunting trip to France and they will be underdogs but they will relish the opportunity to test themselves against what many people regard as the best side in this season's competition.
- Clermont's 46-12 victory over Exeter earlier this season was the French side's biggest against English opposition in the Heineken Cup.
- Exeter Chiefs' lineout success rate of 91% is the best in the Heineken Cup. They've also stolen 10 opposition throws, more than any other team.
- Clermont's Morgan Parra is the tournament's top points scorer. He has 64 to his name having kicked eight conversions and 16 penalties. Exeter's 10 Gareth Steenson is joint-second on the points-scoring list with 50.
- Clermont's David Skrela has amassed 487 points in his Heineken Cup career and will be eyeing 500 in this match.
- If Clermont win this match, it would extend their current run of victories to five and subsequently improve their current club record-breaking run.