The best four Pool winners earn home advantage in April's quarter-finals with Bath Rugby leading that chase on 20 points, Stade Francais Paris next best on 19 and Gloucester currently another point adrift.
They won the Round 2 contest against Bordeaux at Kingsholm 25-13 with wing Charlie Sharples scoring two of their tries and go into the return looking to make it five from five and book their last eight place with a match to spare.
But the 2006 tournament champions will want to welcome Mont de Marsan to Kingsholm in Round 6 with a home quarter-final the ultimate prize.
- Bordeaux have lost each of their last six matches in this tournament, though the last three have been settled by margins of 12 points or less. Should they lose this match, it would extend their worst losing record in this tournament.
- These two teams have a victory each over the other in this tournament.
- Gloucester are enjoying a six-match winning run in this tournament. In four of those wins, the Cherry and Whites have conceded seven points or fewer.
- Gloucester's Freddie Burns has 41 points in two appearances in the Amlin Challenge Cup this season, only Joe Carlisle of Worcester Warriors has more.