Jonny Wilkinson and company lost to fellow French rivals Perpignan in last season's quarter-final, but will want to record a comprehensive bonus point victory over the Sharks.
The Top 14 side, who lost last season's French championship final, already look like genuine challengers for the best side in Europe and a fourth Pool victory would enhance that status.
Sale, who were beaten 17-6 by Toulon in Salford City Stadium, will know they face a tough examination at Stade Felix Mayol which is one of the most intimidating venues in Europe.
The Premiership side have only one victory to their name and are nine points adrift of Toulon.
But Montpellier, who play Welsh side the Cardiff Blues at home, will be hoping the Sharks can cause a major upset and aid their quarter-final hopes by beating the superstars of Toulon.
• Danny Cipriani has kicked the ball in open play on 40 occasions so far this season, the joint-highest total in the tournament.
• Toulon are gunning for their fourth straight victory in the Heineken Cup, which would be their longest ever run of wins in this tournament.
• Sale have not lost three successive matches in one Heineken Cup season since 2004. They have lost their last two.
• In France, Sale have lost six of their eight matches in the Heineken Cup, by an average scoreline of 23-16.