Another victory at the Rec, over Calvisano who are still searching for their first victory in the competition, would see Bath put one foot in the quarter-final stages.
But they will go into the clash without star duo Matt Banahan and Lee Mears. Banahan was red-carded for a dangerous tackle in the club's slender defeat to Leicester on the weekend and has subsequently been slapped with a three-week ban.
Mears was also cited following the ill-tempered encounter and he has been banned for two weeks after being found guilty of striking an opponent.
Francois Louw was also red carded against Leicester but has been cleared to play.
Calvisano go into the clash on the back of a 69-3 victory over L'Aquila.
• Bath Rugby have won their last 11 games in the Amlin Challenge Cup.
• Cammi Rugby Calvisano have only won two of their 14 games played in this competition.
• Samuela Vunisa has registered the most carries (32) in the Amlin Challenge Cup 2012/13.