The Welsh side will still be scratching their heads about how they threw away a 15-point lead in the last quarter against the Premiership outfit in their Pool 6 opener last Sunday.
Phil Davies, the Cardiff Blues Director of Rugby, is under no illusions of the task facing his inexperienced line-up.
"Toulon are a powerful unit, a powerful team and have world-class players in every position times two," said Davies.
"They have a galaxy of stars but we also have our own, which is important.
"It will be a heck of an occasion to test ourselves against one of the best squads in Europe and will be a great opportunity for us.
"Their salary cap is three or four times ours, but we have a group of young players who are up for the challenge. It's a great opportunity to get stuck into them and try to beat them.
"There are a couple of players who stood up and said how excited they are to be facing them. We want the victory and have the opportunity to do it. It's a tall order but I hope the supporters get behind us."
Toulon, which has the likes of England world Cup winner Jonny Wilkinson, South African world cup winner, Bakkies Botha, Wallabies star Matt Giteau and former All Black Carl Heyman in their squad, recorded a comfortable 37-16 victory over Montpellier in the first game of the pool.
The Blues famously beat a star-studded Toulon side 28-21 in the Amlin Challenge Cup final back in 2010.
Toulon teammates Pierrick Gunther and Andrew Sheridan each stole lineout ball on three occasions last week, the joint-highest of the weekend.
Alex Cuthbert defeated three defenders, made three clean breaks and scored three tries in their Heineken Cup opener at Sale last week. Cuthbert has now scored the Blues' last five Heineken Cup tries, only one other player has ever scored five tries in succession in the competition: Tom Beim for Gloucester in 2000.
Cardiff have lost just one of their last 17 home games in the Heineken Cup since 2006: 19-23 to Northampton at Cardiff City Stadium on 19 December 2010.
The two teams have met just once before: the Amlin Challenge Cup final in 2010 at Marseille where the Blues won 28-21.