Their coach Pete Anglesea admits the Sharks view the clash as a chance to kick-start their season and former Cardiff Blues duo Andy Powell and Nick Macleod will have extra incentive to impress.
Their former region are under pressure having lost two home matches in a row.
The Blues will also want to make amends having crashed to a humiliating 34-3 to reigning champions Leinster at last year's quarter-final stage.
It will be the fifth time the two sides have clashed in the Heineken Cup with honours currently even.
The Welsh region were 36-19 victors the last time the two sides clashed.