Edinburgh strengthened their squad in the summer by signing Wales pair Richie Rees and John Yapp as well as the vast experience of double Amlin Challenge Cup winning hooker Andy Titterrell, who is poised to represent his fourth club in Europe.
Tim Visser leads the try scoring in Pro12 with eight already this season but that has not saved the Scottish club from losing their last three games.
Saracens, semi-finalists in 2008, are in good shape for their first trip to Murrayfield.
Mark McCall's men have suffered just one defeat this season and have one of the form fly-halves in England in Charlie Hodgson following his 28-point haul against London Welsh last week.
Chris Ashton will make his European debut for the club following his move from Northampton Saints.