It is five matches - and almost two years - since Bath recorded a victory on the road in Europe which came at Aironi.
Toby Booth's outfit have also had a miserable period in recent weeks on the domestic front with three defeats in their last four Premiership games.
The latest of those losses came in a 16-10 defeat to West Country rivals Gloucester last weekend.
Bath, who are one of only teams alongside London Wasps and Northampton Saints to win both the Heineken and Amlin tournaments, are expected to hand star winger Kyle Eastmond his first taste of European rugby after missing last season through injury.
Bucharest could prove to be tough opponents on the opening weekend as the Romanians have recorded at least one home win in each of their last three seasons at this level.