The Irish outfit have lost just twice at Thomond Park in the Heineken Cup since the tournament's inception in 1995/96, with no French side ever tasting success at the intimidating venue in Limerick.
They also claimed glory the last time the two teams met at the Millennium Stadium in Cardiff in the 2006 Heineken Cup Final and Novès has no doubt that it is his side who will start as heavy underdogs in April.
"We will have absolutely no pressure on the result," said Novès. "If we win, it's a bonus, if we lose, it's normal.
"The last time we played them it was in a final and I have pretty bad memories of that game.
"Munster also hold the record for the number of quarter-final appearances in the Heineken Cup and that speaks for itself. It's a nice challenge for us: whether we are favourites or not, I don't care.
"We will just try and play to our strengths out there. Nobody expects us to win at Munster. But nobody expected us to win at Wembley against Saracens in October and we did."
Toulouse suffered a brace of blows in their final pool game against Zebre at the weekend, with their failure to pick up a try-scoring bonus point against the Italian strugglers ultimately costing them a home quarter-final and injury to captain Thierry Dusautoir hitting their Heineken Cup hopes equally hard.
A four-try success over winless Zebre would have seen Toulouse host Leicester Tigers rather than travel to Munster, while Dusautoir's bicep injury will rule him out of both the quarter-final in Ireland and a potential semi-final with Toulon or Leinster.
"Above all, not playing at home is a disappointment for our fans and our partners. We wanted to please them. They deserved it after going a few years now without seeing a quarter-final at home," added Novès.
"Thierry is not easy to replace, he's simply irreplaceable. On the pitch, in big games, he's always a key player. But we have 23 other players who will go to Munster and and play. At least we will try to play for him."