Former champions Ulster and Leicester Tigers look set to battle it out for top spot in Pool 5 following their bonus-point victories in round three.
Both clubs are only too aware they will each face a backlash from their opponents in Italy and France, respectively, this weekend.
However victories on the road in round four is likely to set up a mouth-watering winner-takes-all clash at Welford Road in the final pool game.
Ulster are the leading points scorers in this year's Heineken Cup and remain one of only two sides who unbeaten so far - compatriots Leinster the other - following their 48-0 demolition of Benetton Treviso at Ravenhill.
However head coach Marc Anscombe hopes his team have learned lessons from the past ahead of their return to Stadio Monigo where Treviso have already beaten Munster and Connacht this season.
He said: "We were sitting over in England this time last year and we were pretty happy with what we had just achieved [following a 25-6 win Northampton]. But we didn't back it up, we let ourselves down and that took away the opportunity of a home quarter-final."
Leicester are the second-highest points scorers in the Heineken Cup season following their thrilling 42-32 win over Montpellier but are braced for a tough examination at Stade Yves du Manoir on Sunday.
Cockerill said: "Montpellier will be looking to knock lumps out of us now in their own back yard, but Ulster have won there so we have got to go looking for a win ourselves. We could do with another five points there."
Pierre Berard's late try ensured Montpellier left Welford Road with a try-bonus though were denied a second point by Ryan Lamb's last-minute drop goal.
Now anything less than maximum points against the Tigers is likely to spell the end of their quarter-final hopes.
Lock Jim Hamilton "The way we came back [at Leicester] will give us some confidence. Next week is a big week for us. Everyone knows what a big tournament the Heineken Cup is and what a great side Leicester are."