Harlequins are on the brink of qualification for the quarter-finals as the aristocrats of English rugby kept their impressive unbeaten run in their Pool against Zebre.
The English champions recorded an emphatic 53-5 win over the new Italian franchise at the Twickenham Stoop and are 10 points ahead of nearest rivals Biarritz Olympique.
Chris Robshaw's side ran in a seven tries - Tom Casson getting the first - to record a bonus-point win and need a solitary point from their remaining two games to secure a lucrative spot in the last eight.
The Londoners have a perfect four out of four record in the Pool so far and play Irish province Connacht and Biarritz in the final two rounds and a win will secure a place in the knockout stages.
Harlequins will now be looking for a vital home draw in the quarter-finals but will know their final two games will not be a walk in the park after Biarritz's 17-0 victory over Connacht Rugby.
The Basque outfit host the English side at the Parc des Sports Aguilera where the Top 14 side have a formidable home record and they still have slim ambitions of a quarter-final place.
Connacht are only a point behind Biarritz and their qualifications hopes are virtually over but they could still dictate who qualifies from the Pool. Zebre are still looking for their first points, let alone first win, in their debut tournament.