Leicester Tigers will go in search of the Pool 2 double over Benetton Treviso at Stadio Comunale Monigo on Saturday without Toby Flood.
The Tigers - back-to-back champions of Europe in 2001 and 2002 - trail group leaders Toulouse by three points but in addition to the six Pool winners the two best runners-up qualify for the prestigious and lucrative quarter-finals.
Director of rugby Richard Cockerill said that Flood - who has scored 382 points in 40 European matches - would be out for a further week with the toe injury he picked up on England duty during the autumn internationals.
Flanker Steve Mafi is also out with a knee problem, but both are expected back for the return to domestic action.
Tigers will also be forced into a change on the flanks with Fijian international Vereniki Goneva having been ruled out with a knee injury. Goneva will probably be out for another four weeks.
Louis Deacon and Anthony Allen are both set to return to the match-day squad, however, as Tigers head to Treviso looking to complete a Heineken Cup double over their Italian opponents.
