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And Jamie Heaslip, the Leinster No 8, will captain his country for the first time when he leads a side that contains debutant Strauss and a further three uncapped players among the replacements.
Among those ruled out through injury were Brian O'Driscoll, Rob Kearney and Paul O'Connell with Mike McCarthy selected in the second row alongside Donnacha Ryan, Chris Henry at openside flanker and Peter O'Mahony at blindside.
In the backs Simon Zebo will be earning his first start for Ireland at full back, in a back three that has plenty of experience in Andrew Trimble and Tommy Bowe, who will be earning his 50th international cap for Ireland since making his debut against the USA in 2004.
Jonathan Sexton and Conor Murray are selected as the halfbacks with Gordon D'Arcy and Keith Earls completing the starting lineup as the centre partnership.
Among the replacements, forwards David Kilcoyne, Michael Bent and Iain Henderson are all in line to make their international debuts should they be called into the game.
