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Bernard Laporte's men scored three tries against the Aviva Premiership leaders having rested a number of their first-choice XV for the previous week's Top 14 trip to Brive.
Bruno and co were in clinical mood at the Stade Felix Mayol and the former Sale star admits they knew they would have to be at the top of their game to see off a Quins side who beat Toulouse on French soil earlier this term.
"We have been playing particularly well in European games. We seem to play our best rugby in European competition," said Bruno.
"Last year, in what was our first Heineken Cup campaign, we put in some good performances to beat Munster and the Ospreys at home and London Irish home and away and two years ago we reached the final of the Amlin Challenge Cup.
"In Europe the game is very offensive, and that suits us. In the Top 14 it is all about the physical approach with rucks, mauls and scrums and we seem to be penalised more often in the Top 14.
"During the week before the Harlequins game we were a little concerned because, when we were watching the video of them, we could see that they did everything at a really fast pace. We were wondering if Aziz Abaakouk (Toulon's video analyst) was playing the video in fast forward!
"During the game itself we focused on being particularly physical. Plus every time they made a mistake, Jonny (Wilkinson) scored three points so that in itself was good for our confidence.
"For us these type of games are very special. We have lots of British people in our team who love to play against a British side and that was an extra motivation.
"We didn't make many mistakes; we were very good defensively; we showed a real tenacity to win the game and we scored every time we had an opportunity. It was a hugely satisfying win for us."
Toulon now entertain Stade back at the Mayol on Friday, April 27 as they aim to make amends for their 2010 Amlin Challenge Cup Final defeat to Cardiff Blues.
The Pool 2 winners will start as favourites thanks to Friday's crushing win and home advantage but Bruno insists they won't be getting carried away against a Parisian outfit that features a number of Toulon old boys.
"The victory against Harlequins was hugely encouraging for us but we must stay calm," added Bruno.
"The week before we were very poor against Brive in the league. Just because we scored 30 points against Quins, it doesn't mean we are going to be world champions. We have to keep our feet on the ground.
"Playing at home is a huge advantage but we have to be careful, especially because Stade Français have a lot of players who played for Toulon in the past, with the likes of Paul Sackey, Felipe Contepomi and George Smith all coming back to the Mayol. Plus, it might be the only way for them to win a title and get a ticket for the Heineken Cup."
