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Harlequins are back in a tournament they won last May - when Bastareaud was with beaten finalists Stade Français Paris - as one of this season's Heineken Cup Pool runners-up and will be up against Toulon for the first time.
"Obviously everyone at Harlequins is really excited about this Amlin Challenge Cup quarter-final and we know Toulon have a tremendously strong squad full of internationals from so many countries," said Lowe.
"However, we will be focusing on ourselves rather that the opposition and if we go for it and produce our best game then anything is possible.
"They have so many big players and with their passionate crowd getting right behind them it is certainly going to be a huge physical challenge.
"I played against Bastareaud in last season's Amlin Challenge Cup final so I know a fair bit about his game and it would be interesting to have another head-to-head with him."
Quins became the first club to win three Amlin Challenge Cup crowns when they beat Stade Français Paris 19-18 in the 2011 Cardiff final, having previously claimed the silverware in 2001 and 2004, but no club has ever managed back-to-back tournament titles.
